产品货号：
Z30204
中文名称：
AntiAMBRA1抗体
英文名称：
AntiAMBRA1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | AntiAMBRA1 Antibody |
| 指标别名 | AMBRA1,autophagy/beclin 1 regulator 1,KIAA1736,WDR94 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | AMBRA1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Ambra1 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human Ambra1.The immunogen is located within the last 50 amino acids of Ambra1. |
| 计算分子量 | 143kDa |
| 成分 | Ambra1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | Ambra1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Autophagy,the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells.It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components.Beclin-1,a principal regulator of autophagosome formation,is in turn regulated by Ambra1.Ambra1 associates with Beclin-1 through a region near its center as determined by yeast two-hybrid assay.Null mutations in this gene in mice resulted in embryonic lethality with severe neural tube defects associated with autophagy impairment,accumulation of ubiquitinated proteins,unbalanced cell proliferation and excessive apoptotic death.Furthermore,down-regulation of Ambra1 in cultured cells though RNA interference decreased the level of rapamycin- and nutrient starvation-induced autophagy.Multiple isoforms of Ambra1 are known to exist. |
| Uniprot ID | Q9C0C7 |
| 基因名全称 | Autophagy/beclin-1 regulator 1 |
| 蛋白名全称 | Autophagy/beclin-1 regulator 1 |
| 推荐稀释比 | Ambra1 antibody can be used for the detection of Ambra1 by Western blot at 1μg/mL.Antibody can also be used for immunohistochemistry starting at 5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in mouse samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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